Description

(1S,2R,5S)-2-Aminomethyl-5-Vinylquinuclidine CAS NO 290817-84-4 is a high-purity, chiral quinuclidine derivative of significant interest in advanced pharmaceutical synthesis. This compound serves as a sophisticated building block and chiral intermediate for the development of active pharmaceutical ingredients (APIs), particularly in the realm of neurological and receptor-targeted therapeutics. Its unique stereochemistry and functional groups make it a critical reagent for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting nicotinic acetylcholine receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the discovery of novel bioactive molecules.
• Asymmetric Synthesis: Employed as a ligand or catalyst component in enantioselective catalytic reactions due to its rigid, three-dimensional structure.
• Process Chemistry & Scale-up: Serves as a starting material or intermediate in the development and optimization of commercial-scale API manufacturing processes.
• Neurological Research Compounds: Integral to the synthesis of compounds for studying neurodegenerative diseases and cognitive disorders.
• High-Value Fine Chemical Production: Used in the production of specialized, high-purity chemicals for advanced research and development.

Basic Information

Product Name	(1S,2R,5S)-2-Aminomethyl-5-Vinylquinuclidine
CAS No.	290817-84-4
Molecular Formula	C11H20N2
Molecular Weight	180.29 g/mol
Synonyms	(1S,2R,5S)-2-(Aminomethyl)-5-vinylquinuclidine; 5-Vinyl-2-aminomethylquinuclidine; (1S,2R,5S)-5-Ethenyl-2-(aminomethyl)quinuclidine; (1S,2R,5S)-2-Aminomethyl-5-vinyl-1-azabicyclo[2.2.2]octane; (1S,2R,5S)-5-Vinylquinuclidin-2-ylmethanamine; ABT-089 Intermediate; GTS-21 Intermediate; TC-1698 Intermediate
EINECS	Contact for details

Quality Control

Our (1S,2R,5S)-2-Aminomethyl-5-Vinylquinuclidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.