Description

tert-Butyl 4-(((2-(Acetoxymethyl)-7-Chloro-3-Methyl-4-Oxo-3,4-Dihydroquinazolin-6-Yl)Methyl)(Prop-2-Ynyl)Amino)Benzoate is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, particularly in constructing novel drug candidates with targeted therapeutic effects. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and API manufacturers focused on innovative small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel quinazolinone-based drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• API Development: Integral in the process development and scale-up of potential active pharmaceutical ingredients.
• Oncology Drug Discovery: Explored for the development of targeted therapies due to the quinazolinone pharmacophore.
• Biochemical Probes: Can be utilized in the design of chemical probes for studying biological pathways and target validation.
• Custom Synthesis: Employed by fine chemical suppliers for the custom manufacturing of specialized compounds for client R&D projects.

Basic Information

Product Name	tert-Butyl 4-(((2-(Acetoxymethyl)-7-Chloro-3-Methyl-4-Oxo-3,4-Dihydroquinazolin-6-Yl)Methyl)(Prop-2-Ynyl)Amino)Benzoate
CAS No.	289686-87-9
Molecular Formula	C27H28ClN3O5
Molecular Weight	510.0 g/mol
Synonyms	tert-Butyl 4-[(2-Acetoxymethyl-7-chloro-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl(prop-2-yn-1-yl)amino]benzoate; 4-(((2-(Acetoxymethyl)-7-Chloro-3-Methyl-4-Oxo-3,4-Dihydroquinazolin-6-Yl)Methyl)(Prop-2-Yn-1-Yl)Amino)Benzoic Acid tert-Butyl Ester; 289686-87-9; 6-[[[4-(1,1-Dimethylethoxy)carbonyl]phenyl](2-propynyl)amino]methyl]-2-(acetoxymethyl)-7-chloro-3-methyl-4(3H)-quinazolinone; Benzoic acid, 4-[[[2-[(acetyloxy)methyl]-7-chloro-3-methyl-4-oxo-3,4-dihydro-6-quinazolinyl]methyl](2-propyn-1-yl)amino]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(((2-(Acetoxymethyl)-7-Chloro-3-Methyl-4-Oxo-3,4-Dihydroquinazolin-6-Yl)Methyl)(Prop-2-Ynyl)Amino)Benzoate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications. We support compliance with cGMP standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.