Description

3-Chloro-5-Fluorophenetole is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound serves as a versatile intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated phenethyl motifs into their target structures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the chloro-fluoro substitution pattern confers specific biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies.
• Functional Polymer Monomer: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and optical properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to create complex aromatic systems.
• Chemical Research & Development: A valuable tool for medicinal chemistry and process chemistry research in academic and industrial R&D laboratories.

Basic Information

Product Name	3-Chloro-5-Fluorophenetole
CAS No.	289039-42-5
Molecular Formula	C8H8ClFO
Molecular Weight	174.60 g/mol
Synonyms	1-Chloro-3-ethoxy-5-fluorobenzene; 3-Chloro-5-fluoro-1-ethoxybenzene; 5-Chloro-3-fluorophenetole; 1-Ethoxy-3-chloro-5-fluorobenzene; Benzene, 1-chloro-3-ethoxy-5-fluoro-; 3-Chloro-5-fluorophenetol; 3-Chloro-5-fluoroanisole, ethoxy derivative
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-5-Fluorophenetole is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard grade meets typical requirements for advanced synthetic intermediates, with comprehensive Certificates of Analysis (COA) provided for each shipment. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.