Description

4-Chloro-3-Fluorophenetole is a versatile halogenated aromatic ether building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents on the phenetole core, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine atom can enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing organic electronic materials, contributing to improved performance in displays and lighting.
• Functional Polymer Monomer: Employed in the synthesis of specialty polymers with specific thermal, chemical, or optical properties.
• Organic Synthesis Reagent: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce functionalized aryl groups.
• Chemical Research & Development: A valuable compound for medicinal chemistry and material science research programs exploring new chemical spaces.

Basic Information

Product Name	4-Chloro-3-Fluorophenetole
CAS No.	289039-33-4
Molecular Formula	C8H8ClFO
Molecular Weight	174.60 g/mol
Synonyms	1-Chloro-2-fluoro-4-ethoxybenzene; 4-Chloro-3-fluoro-1-ethoxybenzene; 3-Fluoro-4-chlorophenetole; 1-Ethoxy-4-chloro-3-fluorobenzene; 4-Chloro-3-fluorophenyl ethyl ether; 2-Fluoro-5-ethoxychlorobenzene; p-Chloro-m-fluorophenetole; Ethyl 4-chloro-3-fluorophenyl ether
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Fluorophenetole is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by advanced analytical techniques including GC, HPLC, and NMR. We are committed to meeting the stringent requirements of our global partners in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.