Description

2-(Bromomethyl)-5-Nitrobenzonitrile is a versatile and high-value brominated aromatic nitrile building block. This compound is critical for the synthesis of complex molecules, particularly in pharmaceutical research and advanced material science. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing nitrile and bromomethyl functional groups for further derivatization.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its reactive sites for constructing heterocyclic systems.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands used in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and polymers where the nitrile and bromo groups impart specific electronic or self-assembly properties.
• Cross-Coupling Reactions: The bromomethyl moiety makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create more complex architectures.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological processes due to its bifunctional reactivity.

Basic Information

Product Name	2-(Bromomethyl)-5-Nitrobenzonitrile
CAS No.	288252-67-5
Molecular Formula	C8H5BrN2O2
Molecular Weight	241.04 g/mol
Synonyms	5-Nitro-2-(bromomethyl)benzonitrile; 2-Bromomethyl-5-nitrobenzonitrile; Benzonitrile, 2-(bromomethyl)-5-nitro-; (2-Bromomethyl-5-nitro-phenyl)-acetonitrile; α-Bromo-5-nitro-o-tolunitrile
EINECS	Contact for details

Quality Control

Our 2-(Bromomethyl)-5-Nitrobenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with your specified requirements. We support cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.