Description

4-Amino-7,8-Difluoro-2-Methylquinoline is a high-purity, multi-functional quinoline derivative serving as a critical building block in advanced organic synthesis. Its value lies in its unique difluoro-substituted quinoline core, which imparts desirable electronic and steric properties for developing novel active compounds. This intermediate is essential for research and development laboratories and production facilities in the pharmaceutical and agrochemical sectors, particularly for creating new active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel fluoroquinolone antibiotics and other bioactive molecules targeting bacterial infections.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a ligand or core structure in the design of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters or charge-transport materials.
• Chemical Biology Probes: Employed to create fluorescent tags or molecular probes for studying biological processes due to the inherent photophysical properties of the quinoline scaffold.
• Catalyst and Ligand Development: The amino and nitrogen heterocycle functionalities make it a candidate for designing novel organocatalysts or metal-chelating ligands.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	4-Amino-7,8-Difluoro-2-Methylquinoline
CAS No.	288151-48-4
Molecular Formula	C10H8F2N2
Molecular Weight	194.18 g/mol
Synonyms	2-Methyl-7,8-difluoro-4-quinolinamine; 7,8-Difluoro-2-methylquinolin-4-amine; 4-Amino-7,8-difluoro-2-methylquinoline; 2-Methyl-7,8-difluoroquinolin-4-ylamine; 4-Quinolinamine, 7,8-difluoro-2-methyl-; 288151-48-4; 7,8-Difluoro-2-methyl-4-aminoquinoline; 4-Amino-7,8-difluoro-2-methyl-quinoline
EINECS	Contact for details

Quality Control

Our 4-Amino-7,8-Difluoro-2-Methylquinoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.