Description

4-Chloro-7,8-Difluoro-2-Methylquinoline is a high-purity, multi-functional heterocyclic building block of significant commercial and research interest. Its unique halogenated quinoline structure makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs). This compound is primarily sought by pharmaceutical R&D and fine chemical synthesis sectors for developing novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel quinoline-based drug candidates, particularly in antimicrobial and anticancer research.
• Agrochemical Synthesis: Used in the production of advanced fungicides and herbicides, leveraging the bioactivity of the difluorinated quinoline core.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for OLEDs.
• Fluorinated Compound Library: An essential building block for medicinal chemistry to expand libraries of fluorinated molecules, which often exhibit improved metabolic stability and membrane permeability.
• Chemical Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Item	Detail
Product Name	4-Chloro-7,8-Difluoro-2-Methylquinoline
CAS No.	288151-46-2
Molecular Formula	C₁₀H₆ClF₂N
Molecular Weight	213.61 g/mol
Synonyms	4-Chloro-7,8-difluoro-2-methylquinoline; 2-Methyl-4-chloro-7,8-difluoroquinoline; 7,8-Difluoro-4-chloro-2-methylquinoline; 288151-46-2; Quinoline, 4-chloro-7,8-difluoro-2-methyl-; 4-Chloro-7,8-difluoro-2-methyl-quinoline
EINECS	Contact for details

Quality Control

Our 4-Chloro-7,8-Difluoro-2-Methylquinoline is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles for pharmaceutical-grade intermediates, ensuring traceability and reliability for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.