Description

4-Bromo-5-Fluorobenzofuran is a high-purity halogenated benzofuran derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both bromine and fluorine substituents, makes it a versatile building block for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, particularly for developing active pharmaceutical ingredients (APIs) and functional organic materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, where the halogen atoms contribute to biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functional unit in the development of organic semiconductors, liquid crystals, and advanced polymers.
• Chemical Biology Probes: Employed as a scaffold for creating fluorescent tags or photoaffinity labels for studying biological processes.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form complex biaryl structures.
• Organic Synthesis Building Block: Utilized in academic and industrial R&D for constructing complex heterocyclic systems and natural product analogs.

Basic Information

Product Name	4-Bromo-5-Fluorobenzofuran
CAS No.	286836-29-1
Molecular Formula	C8H4BrFO
Molecular Weight	215.02 g/mol
Synonyms	5-Fluoro-4-bromobenzofuran; 4-Bromo-5-fluorobenzofuran; Benzofuran, 4-bromo-5-fluoro-; 286836-29-1; 4-Br-5-F-benzofuran
EINECS	Contact for details

Quality Control

Our 4-Bromo-5-Fluorobenzofuran is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.