Description

3-n-Fmoc-3-(4-Methylphenyl)Propionic Acid CAS NO 284492-08-6 is a specialized, high-purity chemical building block featuring both a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group and a p-tolyl-substituted propionic acid moiety. This compound matters for its critical role in the synthesis of complex peptides and other bioactive molecules, where it serves as a key intermediate for introducing specific aromatic side chains under mild, orthogonal deprotection conditions. Pharmaceutical researchers and fine chemical manufacturers need it for advanced drug discovery, particularly in solid-phase peptide synthesis (SPPS) for developing therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the controlled incorporation of non-natural, aromatic amino acid analogs into peptide chains.
• Pharmaceutical Intermediate: Serves as a crucial building block in the research and development of novel therapeutic peptides and peptidomimetic drugs.
• Combinatorial Chemistry: Used in the generation of diverse chemical libraries for high-throughput screening in drug discovery programs.
• Bioconjugation: The carboxylic acid group enables conjugation to other molecules, carriers, or surfaces for creating targeted bioconjugates or probes.
• Organic Synthesis Research: Employed in academic and industrial R&D for constructing complex organic molecules requiring orthogonal protection strategies.
• API Development: Acts as a precursor in the synthesis of Active Pharmaceutical Ingredients (APIs) with specific structural motifs.

Basic Information

Product Name	3-n-Fmoc-3-(4-Methylphenyl)Propionic Acid
CAS No.	284492-08-6
Molecular Formula	C26H24O4
Molecular Weight	400.47 g/mol
Synonyms	3-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(4-methylphenyl)propanoic acid; Fmoc-4-methyl-DL-phenylalanine-OH; 3-[(9-Fluorenylmethoxycarbonyl)amino]-3-(4-methylphenyl)propionic acid; N-Fmoc-4-methylphenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-methyl-L-phenylalanine; Fmoc-4-Me-Phe-OH; 3-(Fmoc-amino)-3-(p-tolyl)propanoic acid; Nα-Fmoc-4-methylphenylalanine
EINECS	Contact for details

Quality Control

Our 3-n-Fmoc-3-(4-Methylphenyl)Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and synthesis. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled accordingly to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.