Description

3-n-Fmoc-3-(4-Methoxyphenyl)Propionic Acid is a high-purity, protected amino acid derivative designed for advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise, high-yield coupling reactions in complex molecule assembly. It is primarily utilized in the pharmaceutical and biotechnology sectors for the solid-phase and solution-phase synthesis of peptides and peptidomimetics, where its Fmoc-protecting group offers orthogonal deprotection strategies essential for modern combinatorial chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and therapeutic peptides.
• Peptide Synthesis: Used extensively in Fmoc-based solid-phase peptide synthesis (SPPS) for the controlled incorporation of non-natural amino acid residues.
• Bioconjugation: Serves as a linker or spacer molecule for attaching functional molecules, labels, or drugs to proteins, antibodies, or other biomolecules.
• Combinatorial Chemistry: Essential for generating diverse compound libraries in drug discovery and medicinal chemistry research.
• Proteomics Research: Employed in the design and synthesis of peptide probes, substrates, and inhibitors for enzyme studies.
• Material Science: Potential use in creating functionalized polymers and advanced materials with specific bioactive properties.

Basic Information

Product Name	3-n-Fmoc-3-(4-Methoxyphenyl)Propionic Acid
CAS No.	284492-02-0
Molecular Formula	C25H22O5
Molecular Weight	402.44 g/mol
Synonyms	Fmoc-3-(4-Methoxyphenyl)propionic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(4-methoxyphenyl)-L-alanine; 3-(4-Methoxyphenyl)-3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]propanoic Acid; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-methoxyphenyl)propanoic Acid; Fmoc-4-MeO-Phe-OH; Fmoc-O-methyl-L-tyrosine; Fmoc-Tyr(Me)-OH; N-α-Fmoc-O-methyl-L-tyrosine
EINECS	Contact for details

Quality Control

Our 3-n-Fmoc-3-(4-Methoxyphenyl)Propionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.