Description

Hydroxy-Peg2-Methylamine CAS NO 282551-10-4 is a bifunctional polyethylene glycol (PEG) derivative featuring a terminal primary amine and a terminal hydroxyl group, separated by a short, flexible PEG spacer. This unique structure makes it an invaluable heterobifunctional crosslinker and spacer for bioconjugation, enabling the controlled attachment of biomolecules, drugs, or labels while improving solubility and reducing steric hindrance. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics industries for developing advanced therapeutics, targeted drug delivery systems, and sensitive assay platforms.

Application

• Bioconjugation and Crosslinking: A key reagent for linking proteins, peptides, antibodies, or oligonucleotides to other molecules, surfaces, or nanoparticles.
• PEGylation of Therapeutics: Used to modify drugs, peptides, or proteins with PEG chains to enhance pharmacokinetic properties, such as increased circulation half-life and reduced immunogenicity.
• Functional Material Synthesis: Serves as a versatile building block for creating functionalized hydrogels, polymer networks, and surface coatings with amine and hydroxyl reactivity.
• Diagnostic Reagent Development: Facilitates the creation of labeled probes and assay components for immunoassays, biosensors, and imaging applications.
• Drug Delivery System Fabrication: Incorporated into micelles, liposomes, or dendrimers to provide functional handles for attaching targeting ligands or therapeutic payloads.
• Solid-Phase Peptide Synthesis (SPPS): Can be used as a soluble support or as a component for introducing PEG spacers into synthetic peptide sequences.

Basic Information

Product Name	Hydroxy-Peg2-Methylamine
CAS No.	282551-10-4
Molecular Formula	C7H17NO4
Molecular Weight	179.22 g/mol
Synonyms	2-[2-(2-Aminoethoxy)ethoxy]ethanol; 2,2'-(Ethylenedioxy)bis(ethylamine) (common misnomer for related compound); Amino-PEG2-alcohol; H2N-PEG2-OH; 1-Amino-3,6-dioxa-8-heptanol; 8-Amino-3,6-dioxa-1-heptanol; 2,2'-(Ethylenedioxy)diethanol, 1-amino derivative; O-(2-Aminoethyl)-O'-(2-hydroxyethyl)diethylene glycol
EINECS	Contact for details

Quality Control

Our Hydroxy-Peg2-Methylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and bioconjugation applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.