Description

5-Chloro-1H-Indole-2-Boronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides, leveraging the indole scaffold's bioactivity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and enzyme inhibitors for biochemical pathway analysis.
• Academic & Contract Research: A vital reagent for methodology development and complex molecule synthesis in academic and industrial R&D laboratories.
• Ligand Synthesis for Catalysis: Used to prepare specialized bidentate ligands for transition metal catalysis.

Basic Information

Product Name	5-Chloro-1H-Indole-2-Boronic Acid
CAS No.	282528-62-5
Molecular Formula	C8H7BClNO2
Molecular Weight	195.41 g/mol
Synonyms	5-Chloro-1H-indole-2-boronic acid; (5-Chloro-1H-indol-2-yl)boronic acid; 5-Chloroindole-2-boronic acid; 2-Borono-5-chloroindole; 5-Chloro-2-indoleboronic acid; Boronic acid, B-(5-chloro-1H-indol-2-yl)-; 282528-62-5
EINECS	Contact for details

Quality Control

Our 5-Chloro-1H-Indole-2-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.