Description

4-Bromo-2-Chloro-1-Ethoxybenzene is a high-purity halogenated aromatic ether building block of significant importance in advanced organic synthesis. Its value lies in its role as a versatile intermediate for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for research chemists and process development scientists working on active pharmaceutical ingredients (APIs), liquid crystal materials, and functionalized ligands for catalysis.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, especially in kinase inhibitor and central nervous system (CNS) active compound libraries.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides and fungicides, leveraging the reactivity of the bromo and chloro substituents for further functionalization.
• Material Science: Serves as a precursor for organic electronic materials and liquid crystals, where the ethoxybenzene core contributes to desired mesomorphic and electronic properties.
• Chemical Research: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to create diverse biaryl and aniline derivatives.
• Fine Chemical Manufacturing: Integral in the multi-step synthesis of dyes, pigments, and other specialty chemicals requiring specific halogenated aromatic motifs.

Basic Information

Product Name	4-Bromo-2-Chloro-1-Ethoxybenzene
CAS No.	279261-80-2
Molecular Formula	C8H8BrClO
Molecular Weight	235.51 g/mol
Synonyms	1-Bromo-4-chloro-2-ethoxybenzene; 2-Chloro-4-bromo-1-ethoxybenzene; 4-Bromo-2-chlorophenetole; 2-Chloro-4-bromophenetole; 1-Ethoxy-4-bromo-2-chlorobenzene; Benzene, 4-bromo-2-chloro-1-ethoxy-; (4-Bromo-2-chlorophenoxy)ethane
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2-Chloro-1-Ethoxybenzene is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation, to ensure compliance with industry standards for fine chemical intermediates. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.