Description

1-Phenylmethyl-L-Histidine Methyl Ester Monohydrochloride is a protected derivative of the essential amino acid L-Histidine, specifically designed for advanced peptide synthesis and pharmaceutical research. This high-purity building block is critical for researchers and manufacturers requiring precise control over molecular structure and stereochemistry in complex organic syntheses. It is primarily utilized by the pharmaceutical, biotechnology, and fine chemical industries for the development of novel therapeutic peptides and biochemical probes.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate histidine residues with protected side chains.
• Biochemical Research: Serves as a precursor for the study of histidine-related biological pathways and enzyme mechanisms.
• Proteomics & Labeling Reagents: Can be utilized in the development of affinity tags, fluorescent probes, or other specialized biochemical tools.
• Fine Chemical Synthesis: Employed in the preparation of complex organic molecules requiring specific histidine derivatives.

Basic Information

Product Name	1-Phenylmethyl-L-Histidine Methyl Ester Monohydrochloride
CAS No.	274927-61-6
Molecular Formula	C15H20N4O2·HCl
Molecular Weight	324.81 g/mol
Synonyms	L-Histidine, Nπ-benzyl-, methyl ester, monohydrochloride; Methyl Nπ-benzyl-L-histidinate hydrochloride; Boc-His(Bzl)-OMe·HCl (related protected form); Histidine benzyl ester hydrochloride; 1-Benzyl-L-histidine methyl ester hydrochloride; Nπ-Benzyl-L-histidine methyl ester hydrochloride; (S)-Methyl 1-benzyl-1H-imidazole-4-carboxylate hydrochloride (tautomeric form)
EINECS	Contact for details

Quality Control

Our 1-Phenylmethyl-L-Histidine Methyl Ester Monohydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity and chiral integrity, meeting the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]D20: Specific range available on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.