Description

Boc-Phe(3-I)-Oh is a protected, non-natural amino acid derivative featuring an iodine substituent on the phenylalanine aromatic ring. This compound is a crucial building block in peptide synthesis, particularly for introducing iodine-labeled or modified tyrosine/phenylalanine analogs to study protein structure, function, and interactions. It is essential for researchers and manufacturers in pharmaceutical development, bioconjugation, and radiopharmaceutical precursor synthesis, where precise chemical modification is required.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key intermediate for incorporating iodinated aromatic amino acids into custom peptide sequences.
• Bioconjugation & Probe Development: Used to create iodine-labeled peptides for imaging studies, fluorescence quenching experiments, or as handles for further cross-linking reactions.
• Radiopharmaceutical Precursors: Serves as a precursor for the synthesis of radioiodinated (e.g., I-125, I-131) peptides and proteins for diagnostic and therapeutic applications.
• Structure-Activity Relationship (SAR) Studies: Enables the exploration of how halogenation affects the biological activity and binding properties of peptide-based drugs.
• Chemical Biology Research: A valuable tool for synthesizing site-specifically modified proteins to investigate post-translational modifications or protein-protein interactions.
• Pharmaceutical Intermediates: Used in the research and development stages of novel therapeutic peptides and peptidomimetics.

Basic Information

Product Name	Boc-Phe(3-I)-Oh
CAS No.	273221-75-3
Molecular Formula	C14H18INO4
Molecular Weight	391.20 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-3-iodo-L-phenylalanine; Boc-3-Iodo-L-phenylalanine; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(3-iodophenyl)propanoic acid; Boc-L-Phe(3-I)-OH; tert-Butyloxycarbonyl-3-iodo-L-phenylalanine; BOC-Phe(3-I)-OH; Boc-3I-Phe-OH
EINECS	Contact for details

Quality Control

Our Boc-Phe(3-I)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric integrity, meeting the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.