Description

3-Methylene-8-Boc-8-Azabicyclo[3.2.1]Octane is a high-purity, advanced pharmaceutical intermediate featuring a protected amine group within a rigid bicyclic framework. This compound is critically valuable for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is primarily needed by research institutions, custom synthesis houses, and pharmaceutical manufacturers engaged in developing novel therapeutics, including alkaloid derivatives and receptor modulators.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug candidates, especially tropane alkaloid analogs.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Neurological Drug Development: Used in the research and production of compounds targeting neurotransmitter systems, such as dopamine and serotonin receptors.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the production of specified APIs under cGMP conditions.
• Process Chemistry & Route Scouting: Acts as a starting material for developing and optimizing scalable synthetic routes for pharmaceutical production.
• Academic Research: Utilized in universities and research institutes for studying organic synthesis methodologies and heterocyclic chemistry.

Basic Information

Product Name	3-Methylene-8-Boc-8-Azabicyclo[3.2.1]Octane
CAS No.	273207-57-1
Molecular Formula	C₁₃H₂₁NO₂
Molecular Weight	223.31 g/mol
Synonyms	8-Boc-3-Methylene-8-azabicyclo[3.2.1]octane; 8-azabicyclo[3.2.1]octane, 3-methylene-, 8-(1,1-dimethylethyl) ester; 3-Methylene-8-[(tert-butoxy)carbonyl]-8-azabicyclo[3.2.1]octane; 8-Boc-3-methylidene-8-azabicyclo[3.2.1]octane; tert-Butyl 3-methylidene-8-azabicyclo[3.2.1]octane-8-carboxylate; 3-Methylene-8-Boc-nortropane; BOC-Protected 3-Methylenenortropane
EINECS	Contact for details

Quality Control

Our 3-Methylene-8-Boc-8-Azabicyclo[3.2.1]Octane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We support development and production needs from laboratory to commercial scale, with quality protocols adaptable to specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the original container tightly sealed under an inert atmosphere when not in use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.