Description

Fmoc-(S)-3-Amino-4-(1-Naphthyl)-Butyric Acid CAS NO 270063-38-2 is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected amine group and a 1-naphthyl side chain. This compound is critically important as a specialized building block for the solid-phase peptide synthesis (SPPS) of peptides with enhanced hydrophobicity and structural complexity. It is primarily needed by research institutions and pharmaceutical companies engaged in developing novel therapeutic peptides, peptidomimetics, and chemical biology probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of custom peptides with bulky, hydrophobic side chains.
• Pharmaceutical Research & Development: Used in the discovery and development of peptide-based drug candidates targeting GPCRs, protein-protein interactions, and enzymes.
• Peptidomimetic Design: Serves as a scaffold for creating non-natural peptide analogs with improved metabolic stability and bioavailability.
• Chemical Biology & Bioconjugation: Employed to introduce naphthyl groups into peptides for fluorescence studies, photolabeling, or as handles for further functionalization.
• Academic Research: Utilized in university and institutional labs for studying peptide structure-activity relationships (SAR) and folding.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to identify bioactive peptide leads.

Basic Information

Product Name	Fmoc-(S)-3-Amino-4-(1-Naphthyl)-Butyric Acid
CAS No.	270063-38-2
Molecular Formula	C29H25NO4
Molecular Weight	451.52 g/mol
Synonyms	Fmoc-3-Amino-4-(1-naphthyl)butanoic acid; Fmoc-3-Amino-4-(naphthalen-1-yl)butyric acid; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(naphthalen-1-yl)butanoic acid; Fmoc-Ahx(1-Nal)-OH; Fmoc-β-homo-1-Nal-OH; N-α-Fmoc-3-amino-4-(1-naphthyl)butyric acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-4-(1-naphthyl)butanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-3-Amino-4-(1-Naphthyl)-Butyric Acid is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive peptide synthesis applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA) documenting identity, assay, and impurity profiles. We adhere to cGMP principles for pharmaceutical-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.