Description

Fmoc-(S)-2-Tetrahydroisoquinoline Acetic Acid is a high-purity, non-natural amino acid derivative featuring a tetrahydroisoquinoline scaffold protected by a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is a critical chiral building block for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, enabling the introduction of constrained, rigid structures into peptide chains. It is primarily utilized by pharmaceutical researchers, biotech companies, and CROs engaged in the development of therapeutic peptides, protease inhibitors, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of novel peptide sequences.
• Peptidomimetic Drug Discovery: Incorporation into peptide backbones to enhance metabolic stability, bioavailability, and receptor binding affinity.
• Protease Inhibitor Development: Used to construct substrate analogs and transition-state mimics for targeting specific proteases.
• Chemical Biology & Probe Design: A versatile scaffold for creating fluorescently labeled or biotinylated probes to study protein-protein interactions.
• Combinatorial Chemistry Libraries: Serves as a valuable input for generating diverse compound libraries focused on peptide-like chemical space.
• Academic & Industrial Research: Fundamental research in medicinal chemistry and organic synthesis for developing new synthetic methodologies.

Basic Information

Product Name	Fmoc-(S)-2-Tetrahydroisoquinoline Acetic Acid
CAS No.	270062-99-2
Molecular Formula	C₂₆H₂₃NO₄
Molecular Weight	413.47 g/mol
Synonyms	Fmoc-Tic-OH; (S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid; Fmoc-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid; Fmoc-(S)-Tic-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid; (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-(S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-2-Tetrahydroisoquinoline Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.