Description

Boc-(S)-2-Tetrahydroisoquinoline Acetic Acid is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This chiral building block is critical for ensuring stereochemical integrity in the development of complex pharmaceutical intermediates and bioactive compounds. It is primarily required by research institutions and pharmaceutical companies engaged in peptide mimetic design, medicinal chemistry, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, receptor antagonists, and other active pharmaceutical ingredients (APIs).
• Peptidomimetics & Constrained Peptides: Used to introduce the rigid tetrahydroisoquinoline scaffold into peptide backbones to enhance metabolic stability and bioavailability.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing combinatorial libraries and exploring structure-activity relationships (SAR).
• Asymmetric Synthesis: Employed in stereoselective reactions to create complex molecules with high enantiomeric purity for preclinical studies.
• Bioconjugation & Probe Development: Useful for labeling and modifying biomolecules in chemical biology research due to its reactive carboxylic acid group.

Basic Information

Product Name	Boc-(S)-2-Tetrahydroisoquinoline Acetic Acid
CAS No.	270062-98-1
Molecular Formula	C₁₆H₂₁NO₄
Molecular Weight	291.34 g/mol
Synonyms	(S)-2-[(tert-Butoxycarbonyl)amino]-1,2,3,4-tetrahydroisoquinoline-3-acetic acid; (3S)-2-[(tert-Butoxycarbonyl)amino]-1,2,3,4-tetrahydro-3-isoquinolineacetic Acid; Boc-Tic-OH; Boc-(S)-Tic-OH; (S)-Boc-1,2,3,4-Tetrahydroisoquinoline-3-acetic Acid; N-Boc-(S)-1,2,3,4-Tetrahydroisoquinoline-3-acetic Acid; N-tert-Butoxycarbonyl-(S)-1,2,3,4-tetrahydroisoquinoline-3-acetic Acid
EINECS	Contact for details

Quality Control

Our Boc-(S)-2-Tetrahydroisoquinoline Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.