Description

Fmoc-(R)-3-Amino-4-(3-Methyl-Phenyl)-Butyric Acid CAS NO 269398-84-7 is a high-purity, non-natural amino acid derivative featuring a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group on the amine and a 3-methylphenyl side chain. This compound is a critical chiral building block designed for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, where it introduces a hydrophobic, aromatic moiety with specific stereochemistry. It is essential for researchers and manufacturers in pharmaceutical development, particularly in creating novel therapeutic peptides, and for use in academic research exploring protein structure-function relationships.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, stepwise construction of custom peptide sequences.
• Pharmaceutical R&D: Used to incorporate a specific (R)-configured, hydrophobic amino acid residue into potential peptide-based drug candidates targeting GPCRs, enzymes, or protein-protein interactions.
• Peptidomimetic Design: Serves as a key intermediate for creating modified peptide analogs with enhanced metabolic stability, bioavailability, or binding affinity.
• Chemical Biology Probes: Employed in the synthesis of labeled or tagged peptides used as tools to study biological pathways and mechanisms.
• Combinatorial Chemistry Libraries: A valuable building block for generating diverse libraries of compounds for high-throughput screening in drug discovery.

Basic Information

Product Name	Fmoc-(R)-3-Amino-4-(3-Methyl-Phenyl)-Butyric Acid
CAS No.	269398-84-7
Molecular Formula	C26H25NO4
Molecular Weight	415.48 g/mol
Synonyms	Fmoc-(R)-3-Amino-4-(3-tolyl)butanoic acid; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(3-methylphenyl)butanoic acid; Fmoc-(R)-3-Amino-4-(m-tolyl)butyric acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-4-(3-methylphenyl)butanoic acid; Fmoc-D-3-Amino-4-(3-methylphenyl)butyric acid; Fmoc-(R)-3-Amino-4-(3-methylphenyl)butanoic acid; Fmoc-(R)-Amp(3-Me)OH; Fmoc-(R)-3-Amino-4-(3-tolyl)butyric acid
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-3-Amino-4-(3-Methyl-Phenyl)-Butyric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, correct stereochemical integrity, and low moisture content, which are critical for efficient peptide synthesis. Certificates of Analysis (COA) detailing purity (HPLC), chiral purity, and other key parameters are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (R-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.