Description

Fmoc-Arg(Me2, Asymmetric)-Oh Hcl is a protected, asymmetric dimethylarginine derivative used in solid-phase peptide synthesis (SPPS). This compound matters for its role in introducing post-translational modifications into synthetic peptides, enabling advanced research into protein function and signaling pathways. It is primarily needed by pharmaceutical R&D teams, biotech companies, and academic laboratories focused on developing peptide-based therapeutics and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled incorporation of asymmetric dimethylarginine into peptide chains.
• Peptide-Based Drug Discovery: Used in the research and development of novel therapeutic peptides targeting protein-protein interactions.
• Biochemical Research: Synthesis of modified peptides for studying enzyme mechanisms, epigenetics, and signal transduction pathways involving arginine methylation.
• Antigen Synthesis: Production of modified peptide antigens for antibody generation and immunological studies.
• Standards and Reference Materials: Serves as a high-purity standard for analytical method development and quality control in peptide manufacturing.

Basic Information

Product Name	Fmoc-Arg(Me2, Asymmetric)-Oh Hcl
CAS No.	268564-10-9
Molecular Formula	C25H32N4O5 • HCl
Molecular Weight	505.01 g/mol
Synonyms	Fmoc-NG,NG'-dimethyl-L-arginine hydrochloride; Fmoc-Asymmetric dimethylarginine hydrochloride; Fmoc-ADMA-OH • HCl; N-α-(9-Fluorenylmethoxycarbonyl)-NG,NG'-dimethyl-L-arginine hydrochloride; Fmoc-NG,NG'-Me2-Arg-OH • HCl; (2S)-5-[(Amino-dimethylamino)methylideneamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid hydrochloride
EINECS	Contact for details

Quality Control

Our Fmoc-Arg(Me2, Asymmetric)-Oh Hcl is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.