Description

(1H-Pyrrolo[3,2-B]Pyridin-5-Yl)Methanamine Dihydrochloride is a high-purity organic building block and pharmaceutical intermediate of significant commercial interest. Its core value lies in its role as a versatile scaffold for the synthesis of novel bioactive compounds, particularly in medicinal chemistry research and development. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.
• Medicinal Chemistry Research: Used as a core scaffold in structure-activity relationship (SAR) studies and lead optimization for novel targets.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new active ingredients for crop protection.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized compounds.
• Academic Research: Employed in university and institutional labs for fundamental organic synthesis and heterocyclic chemistry studies.

Basic Information

Product Name	(1H-Pyrrolo[3,2-B]Pyridin-5-Yl)Methanamine Dihydrochloride
CAS No.	267876-20-0
Molecular Formula	C8H12Cl2N3
Molecular Weight	221.11 g/mol
Synonyms	5-(Aminomethyl)-1H-pyrrolo[3,2-b]pyridine dihydrochloride; 1H-Pyrrolo[3,2-b]pyridin-5-ylmethanamine dihydrochloride; 5-(Aminomethyl)-7-azaindole dihydrochloride; 5-Aminomethyl-1H-pyrrolo[3,2-b]pyridine dihydrochloride; 1H-Pyrrolo[3,2-b]pyridine-5-methanamine dihydrochloride; 5-(Aminomethyl)-1H-pyrrolo[3,2-b]pyridine hydrochloride (1:2)
EINECS	Contact for details

Quality Control

Our (1H-Pyrrolo[3,2-B]Pyridin-5-Yl)Methanamine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.