Description

(2,3-Dihydro-1H-Pyrrolo[2,3-B]Pyridin-5-Yl)Methanamine Dihydrochloride is a high-purity, pharmaceutically relevant organic salt serving as a critical building block in modern drug discovery and development. This compound is essential for medicinal chemists seeking to introduce a fused pyrrolopyridine scaffold with a primary amine handle into target molecules. It is primarily utilized in the research and synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of novel drug candidates, particularly in kinase inhibitor programs.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize lead compounds.
• Bioconjugation & Probe Synthesis: The primary amine group facilitates conjugation with fluorescent dyes, biotin, or other tags for biochemical assay development.
• Chemical Biology: Employed in the synthesis of chemical probes to study enzyme function and biological pathways.
• Library Synthesis: A valuable scaffold for constructing diverse compound libraries for biological screening in drug discovery.
• Process Chemistry Development: Serves as a starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions for clinical trial material.

Basic Information

Product Name	(2,3-Dihydro-1H-Pyrrolo[2,3-B]Pyridin-5-Yl)Methanamine Dihydrochloride
CAS No.	267413-09-2
Molecular Formula	C8H13Cl2N3
Molecular Weight	222.11 g/mol
Synonyms	5-(Aminomethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine dihydrochloride; 1H-Pyrrolo[2,3-b]pyridine-5-methanamine, 2,3-dihydro-, dihydrochloride; 5-(Aminomethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine hydrochloride (1:2); Pyrrolo[2,3-b]pyridine-5-methanamine, 2,3-dihydro-, dihydrochloride; 267413-09-2; (2,3-Dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)methanamine dihydrochloride
EINECS	Contact for details

Quality Control

Our (2,3-Dihydro-1H-Pyrrolo[2,3-B]Pyridin-5-Yl)Methanamine Dihydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency suitable for research and development. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch and supplied upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.