Description

2,5-Difluoro-D-Phenylalanine is a non-natural, fluorinated derivative of the essential amino acid phenylalanine, where two fluorine atoms are strategically substituted on the aromatic ring. This specific structural modification is crucial for enhancing metabolic stability, altering lipophilicity, and influencing receptor binding profiles in bioactive compounds. It serves as a valuable chiral building block for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel peptide-based drugs, enzyme inhibitors, and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and synthesis of fluorinated peptide drugs, protease inhibitors, and other bioactive molecules.
• Proteomics & Biochemistry Research: Used in metabolic pathway studies and as a tool compound to investigate enzyme mechanisms where fluorination alters substrate behavior.
• Positron Emission Tomography (PET) Tracer Development: The fluorine atoms provide sites for radiolabeling (e.g., with F-18) for use in non-invasive imaging agents.
• Agrochemical Research: Employed in the design of novel herbicides and pesticides, where fluorination can improve stability and activity.
• Material Science: Potential precursor for specialized polymers and liquid crystals where fluorinated aromatic groups impart unique physical properties.

Basic Information

Product Name	2,5-Difluoro-D-Phenylalanine
CAS No.	266360-61-6
Molecular Formula	C9H9F2NO2
Molecular Weight	201.17 g/mol
Synonyms	(R)-2-Amino-3-(2,5-difluorophenyl)propanoic acid; D-2,5-Difluorophenylalanine; (2R)-2-Amino-3-(2,5-difluorophenyl)propanoic acid; 2,5-DF-D-Phe; 2,5-Difluoro-D-Phe-OH; 2,5-Difluoro-(R)-Phenylalanine; UNII-9V6G7Q8H1Q
EINECS	Contact for details

Quality Control

Our 2,5-Difluoro-D-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, identity, and impurity profiles. We support compliance with relevant regulatory frameworks for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccants or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (D-Isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.