Description

[Rh (Cod) (-) - Tetrame-Bitiop] Bf4 is a high-purity, chiral organorhodium complex widely utilized as a specialized catalyst in asymmetric synthesis. This compound matters for its ability to facilitate highly enantioselective transformations, a critical requirement in the production of active pharmaceutical ingredients (APIs) and advanced fine chemicals. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors seeking to develop novel chiral molecules with high optical purity.

Application

• Asymmetric Hydrogenation: A key catalyst for the enantioselective reduction of prochiral olefins, enamides, and ketones in pharmaceutical intermediate synthesis.
• Pharmaceutical Research & Development: Enables the creation of single-enantiomer drug candidates for oncology, central nervous system (CNS), and cardiovascular therapies.
• Agrochemical Synthesis: Used in the production of chiral herbicides, fungicides, and plant growth regulators with enhanced efficacy and environmental profile.
• Fine Chemical Manufacturing: Applied in the synthesis of complex fragrance ingredients, advanced materials, and other high-value specialty chemicals.
• Academic & Process Chemistry: Serves as a benchmark catalyst for methodological development and studying mechanistic pathways in asymmetric catalysis.
• Scale-up Process Optimization: Employed in pilot plants and commercial production lines where high catalyst turnover and selectivity are paramount.

Basic Information

Product Name	[Rh (Cod) (-) - Tetrame-Bitiop] Bf4
CAS No.	266316-99-8
Molecular Formula	C₂₀H₃₂BF₄P₂Rh
Molecular Weight	528.02 g/mol
Synonyms	(-)-Tetrame-Bitiop Rhodium(I) Tetrafluoroborate; (1,5-Cyclooctadiene)[(2S,3S)-(-)-2,3-Bis(tert-butylmethylphosphino)quinoxaline]rhodium(I) Tetrafluoroborate; Rh(COD)[(-)-TMBTP]BF₄; Rh-TMBTP Catalyst; Asymmetric Hydrogenation Catalyst Rh-TMBTP; Rh(I)-(S,S)-TMBTP Complex; Chiral Rhodium Diphosphine Complex
EINECS	Contact for details

Quality Control

Every batch of our [Rh (Cod) (-) - Tetrame-Bitiop] Bf4 is synthesized and purified under controlled conditions to ensure exceptional consistency and catalytic performance. We employ advanced analytical techniques including NMR, HPLC, and elemental analysis to verify identity, chiral purity (>99% ee typical), and chemical purity (>98% typical). Certificates of Analysis (COA) with full characterization data are provided with each shipment, supporting compliance with cGMP and ICH guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive and light-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Rhodium Content (ICP-MS)	19.0 - 20.0%
Solubility	Soluble in dichloromethane, acetone; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.