Description

Quinazoline, 4-Chloro-6-Methoxy-7-[3-(4-Methyl-1-Piperazinyl)Propoxy]- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial importance for its role as a key building block in the synthesis of targeted therapeutic agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of proprietary drug candidates, especially kinase inhibitors.
• Oncology Research: Used in the research and development of targeted cancer therapies due to its quinazoline core, a common pharmacophore in many anti-cancer agents.
• Chemical Biology & Proteomics: Employed as a tool compound or a scaffold for creating chemical probes to study specific biological pathways and protein functions.
• Process Chemistry & Scale-Up: Utilized in process development and optimization studies for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development programs for global pharmaceutical companies.
• Academic Research: Used in university and institutional labs for medicinal chemistry projects and the synthesis of novel chemical entities for biological screening.

Basic Information

Product Name	Quinazoline, 4-Chloro-6-Methoxy-7-[3-(4-Methyl-1-Piperazinyl)Propoxy]-
CAS No.	264208-55-1
Molecular Formula	C17H23ClN4O2
Molecular Weight	350.85 g/mol
Synonyms	4-Chloro-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazoline; 7-[3-(4-Methyl-1-piperazinyl)propoxy]-4-chloro-6-methoxyquinazoline; 4-Chloro-7-(3-(4-methylpiperazin-1-yl)propoxy)-6-methoxyquinazoline; TAK-285 Intermediate; ARQ 197 Related Compound; C-Met Inhibitor Intermediate; Volitinib Intermediate; Savolitinib Intermediate
EINECS	Contact for details

Quality Control

Our Quinazoline, 4-Chloro-6-Methoxy-7-[3-(4-Methyl-1-Piperazinyl)Propoxy]- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.