Description

n-Boc-4-(Methylamino)Benzoic Acid is a high-purity, protected amino acid derivative widely used as a critical building block in organic synthesis. This compound is essential for researchers and manufacturers requiring precise molecular construction, particularly in the development of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). Its primary value lies in providing a versatile and stable scaffold for peptide coupling and other coupling reactions, where the tert-butoxycarbonyl (Boc) protecting group offers selective deprotection advantages. Key industries that rely on this chemical include pharmaceutical R&D, contract manufacturing organizations (CMOs), and fine chemical producers focused on advanced life science applications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Peptidomimetic Synthesis: Used to incorporate modified benzoic acid motifs into peptide chains, creating analogs with enhanced stability or bioavailability.
• Protecting Group Chemistry: Serves as a reagent where the Boc group is required for temporary protection of amine functionalities during multi-step synthetic sequences.
• Linker Molecule for Bioconjugation: Facilitates the covalent attachment of small molecules to larger biomolecules like proteins or antibodies in ADC (Antibody-Drug Conjugate) research.
• Material Science Research: Employed in the development of specialty polymers and functional organic materials that require aromatic amino acid components.
• Academic & Industrial R&D: A valuable tool for chemists in universities and corporate labs exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	n-Boc-4-(Methylamino)Benzoic Acid
CAS No.	263021-30-3
Molecular Formula	C13H17NO4
Molecular Weight	251.28 g/mol
Synonyms	4-[(tert-Butoxycarbonyl)(methyl)amino]benzoic acid; 4-[(tert-Butoxycarbonyl)methylamino]benzoic acid; 4-(N-Boc-N-methylamino)benzoic acid; N-Boc-N-methyl-4-aminobenzoic acid; N-(tert-Butoxycarbonyl)-N-methyl-4-aminobenzoic acid; Boc-4-(Methylamino)benzoic Acid; tert-Butyl 4-carboxy-N-methylphenylcarbamate; BOC-MABA
EINECS	Contact for details

Quality Control

Our n-Boc-4-(Methylamino)Benzoic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP manufacturing. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed immediately after use to prevent degradation from atmospheric moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.