Description

3-(Trifluoromethyl)Bicyclo[1.1.1]Pentan-1-Aminehydrochloride is a high-value, structurally constrained bicyclic amine hydrochloride salt featuring a strategically positioned trifluoromethyl group. This compound is a critical building block in modern medicinal chemistry, prized for its ability to modulate the physicochemical properties of drug candidates, such as enhancing metabolic stability and membrane permeability. It is primarily sought after by pharmaceutical R&D and agrochemical innovators for the synthesis of novel active ingredients targeting a range of therapeutic and crop protection applications.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small molecule drugs, particularly in central nervous system (CNS), oncology, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for specialty polymers and advanced materials requiring unique fluorine-containing motifs.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed as a linker or warhead component in the design of targeted protein degradation molecules.
• Ligand & Catalyst Development: Utilized to create novel ligands for catalysis or as a scaffold in organometallic chemistry.
• Fluorine Chemistry Building Block: Provides a source of a rigid, aliphatic trifluoromethylated amine for diverse synthetic transformations in discovery chemistry.

Basic Information

Product Name	3-(Trifluoromethyl)Bicyclo[1.1.1]Pentan-1-Aminehydrochloride
CAS No.	262852-11-9
Molecular Formula	C7H9ClF3N
Molecular Weight	199.60 g/mol
Synonyms	3-(Trifluoromethyl)bicyclo[1.1.1]pentan-1-amine hydrochloride; 1-Amino-3-(trifluoromethyl)bicyclo[1.1.1]pentane hydrochloride; 3-(Trifluoromethyl)-1-bicyclo[1.1.1]pentanamine hydrochloride; Bicyclo[1.1.1]pentan-1-amine, 3-(trifluoromethyl)-, hydrochloride; 3-(Trifluoromethyl)bicyclo[1.1.1]pentan-1-amine HCl; 262852-11-9; 3-Trifluoromethylbicyclo[1.1.1]pentan-1-amine hydrochloride
EINECS	Contact for details

Quality Control

Our production of 3-(Trifluoromethyl)Bicyclo[1.1.1]Pentan-1-Aminehydrochloride adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with cGMP, ISO, and other relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccated environment after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.