Description

2-Methyl-4-(Trifluoromethoxy)Benzoic Acid is a high-value, multi-functional aromatic carboxylic acid derivative, distinguished by its trifluoromethoxy substituent. This compound is a critical synthetic intermediate prized for its ability to impart metabolic stability and lipophilicity to target molecules. It is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays (LCDs).
• Polymer & Material Science: Employed as a monomer or modifier to create specialty polymers with unique thermal, chemical, or surface properties.
• Organic Synthesis & Catalysis: Acts as a versatile reagent in coupling reactions (e.g., Suzuki, Heck) and as a ligand precursor in catalytic systems.
• Chemical Research (R&D): A valuable tool for medicinal and process chemistry in both academic and industrial settings for structure-activity relationship (SAR) studies.

Basic Information

Item	Detail
Product Name	2-Methyl-4-(Trifluoromethoxy)Benzoic Acid
CAS No.	261951-91-1
Molecular Formula	C9H7F3O3
Molecular Weight	220.15 g/mol
Synonyms	2-Methyl-4-(trifluoromethoxy)benzoic acid; 4-(Trifluoromethoxy)-2-methylbenzoic acid; 2-Methyl-α,α,α-trifluoro-p-anisic acid; Benzoic acid, 2-methyl-4-(trifluoromethoxy)-; 261951-91-1
EINECS	Contact for details

Quality Control

Every batch of 2-Methyl-4-(Trifluoromethoxy)Benzoic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment. Our quality protocols are designed to support applications requiring cGMP compliance and regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. Due to its acidic nature, handle with appropriate engineering controls and personal protective equipment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.