Description

4-Bromo-8-Trifluoromethylquinoline is a high-value, multi-functional halogenated quinoline derivative that serves as a critical building block in advanced organic synthesis. Its unique molecular structure, featuring both bromine and trifluoromethyl substituents, makes it an indispensable intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly for targets requiring the quinoline scaffold, such as kinase inhibitors, antimicrobials, and anticancer agents.
• Agrochemical Research: Used in developing new generations of pesticides, herbicides, and fungicides, where the trifluoromethyl group can enhance biological activity and metabolic stability.
• Material Science: Serves as a building block for creating organic electronic materials, including ligands for OLEDs and charge-transport materials, due to its electron-deficient quinoline core.
• Chemical Synthesis: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitutions, where the bromine atom acts as a versatile handle for further functionalization.
• Ligand & Catalyst Development: Employed in the design of novel ligands for transition metal catalysis, leveraging the coordinating ability of the nitrogen atom in the quinoline ring.

Basic Information

Product Name	4-Bromo-8-Trifluoromethylquinoline
CAS No.	260973-10-2
Molecular Formula	C10H5BrF3N
Molecular Weight	276.06 g/mol
Synonyms	8-Trifluoromethyl-4-bromoquinoline; 4-Bromo-8-(trifluoromethyl)quinoline; Quinoline, 4-bromo-8-(trifluoromethyl)-; 4-Bromo-8-trifluoromethyl-quinoline; 260973-10-2
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-8-Trifluoromethylquinoline is manufactured under strict quality management protocols. We employ advanced analytical techniques, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.