Description

4-Bromo-8-Methyl-2-(Trifluoromethyl)Quinoline is a high-value, multi-functional heterocyclic building block. This compound is engineered to serve as a critical intermediate in advanced organic synthesis, offering unique reactivity due to its bromo and trifluoromethyl substituents. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the quinoline scaffold and halogen atoms contribute to biological activity.
• Material Science: Serves as a building block for organic light-emitting diodes (OLEDs), liquid crystals, and other advanced electronic materials due to its electron-deficient quinoline core.
• Chemical Synthesis: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitutions, where the bromine atom acts as a versatile handle for further functionalization.
• Ligand and Catalyst Development: The nitrogen atom in the quinoline ring makes it a suitable candidate for constructing chelating ligands in transition metal catalysis.

Basic Information

Product Name	4-Bromo-8-Methyl-2-(Trifluoromethyl)Quinoline
CAS No.	260973-04-4
Molecular Formula	C₁₁H₇BrF₃N
Molecular Weight	290.08 g/mol
Synonyms	4-Bromo-8-methyl-2-(trifluoromethyl)quinoline; 2-(Trifluoromethyl)-4-bromo-8-methylquinoline; 8-Methyl-4-bromo-2-trifluoromethylquinoline; Quinoline, 4-bromo-8-methyl-2-(trifluoromethyl)-; 260973-04-4
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-8-Methyl-2-(Trifluoromethyl)Quinoline is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthesis. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles via HPLC, NMR, and GC-MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.