Description

tert-Butyl 2-Cyano-7,8-Dihydro-1,6-Naphthyridine-6(5H)-Carboxylate is a high-value, protected heterocyclic building block essential for advanced organic synthesis. This compound matters because it serves as a critical intermediate in the development of complex pharmaceutical molecules, particularly in medicinal chemistry programs targeting kinase inhibition. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to streamline the synthesis of novel drug candidates, leveraging its reactive cyano and protected amine functionalities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of small molecule kinase inhibitors and other biologically active compounds.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for drug discovery.
• Chemical Synthesis Building Block: Employed in constructing complex naphthyridine and fused heterocyclic scaffolds.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for developing new synthetic methodologies.

Basic Information

Product Name	tert-Butyl 2-Cyano-7,8-Dihydro-1,6-Naphthyridine-6(5H)-Carboxylate
CAS No.	259809-46-6
Molecular Formula	C14H17N3O2
Molecular Weight	259.31 g/mol
Synonyms	6-(tert-Butoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-2-carbonitrile; 2-Cyano-5,6,7,8-tetrahydro-1,6-naphthyridine-6(5H)-carboxylic acid tert-butyl ester; tert-Butyl 2-cyano-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate; Boc-Protected 2-Cyano-5,6,7,8-tetrahydro-1,6-naphthyridine; 259809-46-6; TB-2-Cyano-DHN-Carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Cyano-7,8-Dihydro-1,6-Naphthyridine-6(5H)-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.