Description

(1R,2S)-Methyl 1-Amino-2-Vinylcyclopropanecarboxylate Hcl CAS NO 259214-58-9 is a high-purity, chiral cyclopropane derivative that serves as a critical building block in advanced organic synthesis. Its unique, strained three-membered ring structure and functional handles make it an invaluable intermediate for constructing complex molecular architectures with high stereochemical control. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the creation of novel pesticides and herbicides, where the cyclopropane ring can impart unique biological activity and stability.
• Asymmetric Catalysis Research: Employed as a sophisticated ligand precursor or substrate in the development of new catalytic systems for stereoselective transformations.
• Fine Chemical Production: Serves as a building block for the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & Industrial R&D: A valuable tool for synthetic organic chemists in universities and corporate labs exploring new reaction methodologies and complex molecule synthesis.
• Peptidomimetic & Prodrug Development: Its amino ester functionality makes it suitable for constructing peptide analogs and designing prodrugs with enhanced properties.

Basic Information

Product Name	(1R,2S)-Methyl 1-Amino-2-Vinylcyclopropanecarboxylate Hydrochloride
CAS No.	259214-58-9
Molecular Formula	C8H13NO2 • HCl
Molecular Weight	191.65 g/mol (Free base: 155.19 g/mol)
Synonyms	Methyl (1R,2S)-1-amino-2-vinylcyclopropanecarboxylate hydrochloride; (1R,2S)-1-Amino-2-vinylcyclopropanecarboxylic acid methyl ester hydrochloride; (1R,2S)-Methyl 1-amino-2-vinylcyclopropanecarboxylate HCl; trans-Methyl 1-amino-2-vinylcyclopropanecarboxylate hydrochloride; Vince Lactam Intermediate Derivative; Cyclopropane amino ester hydrochloride; CAS 259214-58-9
EINECS	Contact for details

Quality Control

Our (1R,2S)-Methyl 1-Amino-2-Vinylcyclopropanecarboxylate Hcl is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding R&D and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, chiral purity, and impurity profiles. Our quality systems are designed to support cGMP compliance for pharmaceutical development, and we can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (1R,2S)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single unknown impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.