Description

Quinoline, 8-[(4R)-4-(1,1-Dimethylethyl)-4,5-Dihydro-2-Oxazolyl]- is a high-purity, chiral oxazoline-substituted quinoline derivative, serving as a sophisticated building block in advanced organic synthesis. This compound matters for its role as a key ligand precursor or intermediate in the development of asymmetric catalysts and active pharmaceutical ingredients (APIs). It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to create novel, optically active molecules.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel drug candidates, particularly in areas requiring high stereoselectivity.
• Catalyst Ligand Precursor: Used in the preparation of specialized ligands for transition metal-catalyzed asymmetric reactions, such as hydrogenations and cross-couplings.
• Agrochemical Research: Serves as an intermediate in the development of new, more effective pesticides and herbicides with targeted activity.
• Material Science: Employed in the research of advanced organic materials, including liquid crystals and organic semiconductors.
• Academic & Industrial R&D: A valuable tool for chemists in both university and corporate settings exploring new synthetic methodologies and complex molecule construction.

Basic Information

Product Name	Quinoline, 8-[(4R)-4-(1,1-Dimethylethyl)-4,5-Dihydro-2-Oxazolyl]-
CAS No.	259105-53-8
Molecular Formula	C₁₆H₂₀N₂O
Molecular Weight	256.34 g/mol
Synonyms	(R)-8-(4-tert-Butyl-4,5-dihydrooxazol-2-yl)quinoline; (4R)-4-(1,1-Dimethylethyl)-2-(8-quinolinyl)-4,5-dihydro-1,3-oxazole; 2-(Quinolin-8-yl)-4-tert-butyl-4,5-dihydrooxazole (R enantiomer); (R)-2-(8-Quinolyl)-4-tert-butyl-2-oxazoline; (R)-TBQO; (R)-8-(4-tert-Butyl-2-oxazolinyl)quinoline; Quinoline, 8-[(4R)-4-tert-butyl-4,5-dihydro-2-oxazolyl]-; (R)-8-(4-tert-Butyl-4,5-dihydrooxazol-2-yl)chinolin
EINECS	Contact for details

Quality Control

Our Quinoline, 8-[(4R)-4-(1,1-Dimethyl ethyl)-4,5-Dihydro-2-Oxazolyl]- is manufactured under strict quality protocols to ensure batch-to-batch consistency and high chiral purity. Each lot undergoes comprehensive analysis, including chiral HPLC for enantiomeric excess (ee) determination, NMR, and mass spectrometry for structural confirmation. Certificates of Analysis (COA) with full analytical data are provided to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled and stored accordingly to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.