Description

3,6,9,12-Tetraoxatetradecan-1-Ol, 14-(4-Nitrophenoxy)- is a specialized polyethylene glycol (PEG) derivative functionalized with a terminal nitrophenoxy group. This compound is valued for its role as a versatile chemical intermediate and linker, offering a unique combination of water solubility from the PEG chain and reactivity from the aromatic nitro moiety. It is primarily sought by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications in bioconjugation, polymer synthesis, and surface modification.

Application

• Pharmaceutical Intermediate: Used in the synthesis of prodrugs, targeted drug delivery systems, and as a linker for attaching therapeutic agents to carriers like antibodies or nanoparticles.
• Bioconjugation Reagent: Serves as a heterobifunctional crosslinker for coupling biomolecules (e.g., proteins, peptides) due to the reactive nitro group, which can be further reduced to an amine for additional coupling chemistry.
• Polymer Chemistry: Acts as a functional initiator or monomer for creating novel amphiphilic block copolymers and PEGylated materials with tailored properties.
• Surface Functionalization: Employed to modify material surfaces (e.g., gold, silica) to introduce PEG chains for creating non-fouling, biocompatible coatings.
• Research & Development: A key building block in academic and industrial R&D for exploring new drug delivery platforms and smart material designs.
• Diagnostic Agent Synthesis: Potential use in constructing components for diagnostic assays and imaging probes.

Basic Information

Product Name	3,6,9,12-Tetraoxatetradecan-1-Ol, 14-(4-Nitrophenoxy)-
CAS No.	256479-09-1
Molecular Formula	C18H29NO8
Molecular Weight	387.43 g/mol
Synonyms	14-(4-Nitrophenoxy)-3,6,9,12-tetraoxatetradecan-1-ol; 4-Nitrophenyl-PEG4-alcohol; 4-Nitrophenyl tetraethylene glycol; 4-NP-PEG4-OH; 2-[2-[2-[2-[2-(4-Nitrophenoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol; Nitro-PEG4-alcohol; α-(4-Nitrophenoxy)-ω-hydroxy-tetraethylene glycol; PEG4-(4-nitrophenyl) ether
EINECS	Contact for details

Quality Control

Our 3,6,9,12-Tetraoxatetradecan-1-Ol, 14-(4-Nitrophenoxy)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP-compliant production for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.