Description

4-Cbz-Morpholine-3-Carboxylic Acid is a high-purity, protected morpholine derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and novel chemical entities. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for their synthetic pathways.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of potential drug candidates, including protease inhibitors and other biologically active molecules.
• Peptidomimetics Research: Used to incorporate constrained morpholine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Synthesis: Intermediate in the research and development of new herbicides, fungicides, and insecticides with improved efficacy.
• Custom Chemical Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring specialized heterocyclic chemistry.
• Academic Research: A valuable tool in university and institutional labs for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	4-Cbz-Morpholine-3-Carboxylic Acid
CAS No.	256446-67-0
Molecular Formula	C13H15NO5
Molecular Weight	265.26 g/mol
Synonyms	4-[(Benzyloxy)carbonyl]morpholine-3-carboxylic acid; 3-Carboxy-4-[(phenylmethoxy)carbonyl]morpholine; 4-Carbobenzyloxy-morpholine-3-carboxylic Acid; 4-Cbz-3-morpholinecarboxylic acid; N-Cbz-3-morpholinecarboxylic acid; 4-(Benzyloxycarbonyl)morpholine-3-carboxylic acid; 4-(Phenylmethoxycarbonyl)morpholine-3-carboxylic acid; 256446-67-0
EINECS	Contact for details

Quality Control

Every batch of 4-Cbz-Morpholine-3-Carboxylic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are suitable for use in GMP and non-GMP applications, with specifications tailored to meet rigorous research and development needs. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.