Description

(E)-3-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-2-Propenenitrile is a high-purity, advanced pharmaceutical intermediate characterized by its specific quinoline-based molecular architecture. This compound is of significant commercial importance for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in drug discovery and development programs, particularly for targeting specific disease pathways.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and commercial production of targeted therapeutic agents.
• Drug Discovery & Development: Utilized in medicinal chemistry for the design and synthesis of new chemical entities (NCEs) with potential biological activity.
• API Synthesis: Integrated into multi-step synthetic routes for the manufacture of complex final active pharmaceutical ingredients.
• Biochemical Research: Employed as a standard or reagent in studies investigating enzyme inhibition or receptor binding mechanisms.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	(E)-3-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-2-Propenenitrile
CAS No.	256431-72-8
Molecular Formula	C21H15FN2
Molecular Weight	314.36 g/mol
Synonyms	(E)-3-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)acrylonitrile; 2-Propenenitrile, 3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-, (E)-; 256431-72-8; 3-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)acrylonitrile; (E)-3-(2-Cyclopropyl-4-(p-fluorophenyl)-3-quinolyl)acrylonitrile
EINECS	Contact for details

Quality Control

Our production of (E)-3-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-2-Propenenitrile adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, guaranteeing traceability and compliance with your research or cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The material should be kept under an inert atmosphere if long-term storage is anticipated to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.