Description

1H-Indene-2-Carboxylic Acid, 2-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-2,3-Dihydro-, Ethyl Ester is a high-purity, protected amino acid derivative featuring a unique indene carboxylic acid scaffold. This compound is a critical advanced pharmaceutical intermediate (API) designed for the synthesis of complex bioactive molecules, offering precise stereochemistry and functional group compatibility. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, including protease inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the multi-step synthesis of active pharmaceutical ingredients (APIs) for target-oriented drug discovery.
• Protease Inhibitor Research: Used in the design and development of novel inhibitors targeting specific proteases, such as HIV protease or hepatitis C virus NS3/4A protease.
• Peptidomimetics Synthesis: The protected amino acid structure makes it valuable for constructing non-peptide scaffolds that mimic peptide function, enhancing metabolic stability.
• Medicinal Chemistry & Lead Optimization: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of drug candidates.
• Asymmetric Synthesis: Acts as a chiral synthon in stereoselective reactions to introduce complex molecular architectures with high enantiomeric purity.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds or probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	1H-Indene-2-Carboxylic Acid, 2-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-2,3-Dihydro-, Ethyl Ester
CAS No.	255906-25-3
Molecular Formula	C18H23NO4
Molecular Weight	317.38 g/mol
Synonyms	Ethyl 2-[(tert-Butoxycarbonyl)amino]-2,3-dihydro-1H-indene-2-carboxylate; 2-[(Boc)amino]-2,3-dihydro-1H-indene-2-carboxylic Acid Ethyl Ester; Boc-2-aminoindane-2-carboxylic Acid Ethyl Ester; 2-(Boc-amino)indane-2-carboxylic Acid Ethyl Ester; (2,3-Dihydro-1H-inden-2-yl)-Boc-amino Acetic Acid Ethyl Ester; 255906-25-3; tert-Butyl N-(2-ethoxycarbonyl-2,3-dihydro-1H-inden-2-yl)carbamate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay, chiral purity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.