Description

Tricyclohexylphosphine[1,3-Bis(2,4,6-Trimethylphenyl)Imidazol-2-Ylidene][3-Phenyl-1H-Inden-1-Ylidene]Ruthenium (II) Dichloride is a highly specialized, third-generation Grubbs-type olefin metathesis catalyst. This compound matters for its exceptional thermal stability and functional group tolerance, enabling complex synthetic transformations under mild conditions. It is critically needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures, including macrocycles and polymers.

Application

• Pharmaceutical Intermediate Synthesis: Key for ring-closing metathesis (RCM) in the production of active pharmaceutical ingredients (APIs), particularly for macrocyclic drugs.
• Agrochemical Development: Used in the synthesis of novel, complex molecules for crop protection agents and herbicides.
• Advanced Polymer Chemistry: Enables precise control in ring-opening metathesis polymerization (ROMP) for creating specialty polymers and functional materials.
• Fine Chemical and Fragrance Manufacturing: Facilitates the efficient construction of complex olefinic structures in high-value specialty chemicals.
• Academic and Industrial R&D: A vital tool for methodological development in organic synthesis and catalysis research.
• Cross-Metathesis Reactions: Applied in the synthesis of fine chemicals and novel olefinic compounds through efficient cross-coupling.

Basic Information

Product Name	Tricyclohexylphosphine[1,3-Bis(2,4,6-Trimethylphenyl)Imidazol-2-Ylidene][3-Phenyl-1H-Inden-1-Ylidene]Ruthenium (II) Dichloride
CAS No.	254972-49-1
Molecular Formula	C58H72Cl2N2PRu
Molecular Weight	974.06 g/mol
Synonyms	Grubbs Catalyst 3rd Generation; Grubbs-Hoveyda Catalyst 2nd Generation (modified); [1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(3-phenyl-1H-inden-1-ylidene)(tricyclohexylphosphine)ruthenium; Dichloro[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene](3-phenyl-1H-inden-1-ylidene)(tricyclohexylphosphine)ruthenium(II); Hoveyda-Grubbs Catalyst 2nd Gen; Zhan Catalyst 1B; Ru-IndenyliDene Catalyst; (H2IMes)(PCy3)(Cl)2Ru=CHPh
EINECS	Contact for details

Quality Control

Our high-purity metathesis catalysts are manufactured and handled under stringent inert atmosphere conditions to ensure optimal activity. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and elemental analysis, to verify identity, purity, and catalytic performance. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a dry, cold environment. This material is moisture-sensitive and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will degrade catalytic activity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Purple to brown crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Solubility	Soluble in common organic solvents (DCM, toluene, THF)
Elemental Analysis	Within theoretical range

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.