Description

4-Bromo-1-Methyl-2-(Methylsulfonyl)Benzene is a high-purity, functionalized aromatic sulfone building block of significant importance in advanced organic synthesis. Its unique structure, featuring both bromo and methylsulfonyl substituents, makes it a versatile intermediate for constructing complex molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring sulfone or aryl bromide functional groups for further cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the sulfone moiety can contribute to biological activity.
• Material Science Research: Serves as a monomer or building block for the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed reactions like Suzuki, Negishi, or Buchwald-Hartwig amination, enabling rapid diversification of molecular scaffolds.
• Chemical Library Development: Employed in medicinal and combinatorial chemistry for the parallel synthesis of diverse compound libraries aimed at drug discovery.
• Ligand and Catalyst Preparation: Useful for synthesizing novel ligands or organocatalysts containing sulfone groups, which can influence reactivity and selectivity.

Basic Information

Product Name	4-Bromo-1-Methyl-2-(Methylsulfonyl)Benzene
CAS No.	254887-17-7
Molecular Formula	C9H9BrO2S
Molecular Weight	261.14 g/mol
Synonyms	2-Bromo-5-methylphenyl methyl sulfone; 1-Bromo-4-methyl-2-(methylsulfonyl)benzene; 4-Bromo-2-methylsulfonyltoluene; 4-Bromo-o-tolyl methyl sulfone; 2-Methyl-5-bromophenyl methyl sulfone; Methyl (2-bromo-5-methylphenyl) sulfone; 254887-17-7
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-1-Methyl-2-(Methylsulfonyl)Benzene is produced and tested under a strict quality management system to ensure consistency and reliability for your critical research and development processes. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.