Description

6-Chloro-4-(2-Cyclopropylethynyl)-4-(Trifluoromethyl)-1,3-Dihydroquinolin-2-One is a high-value, synthetically complex organic intermediate featuring a unique quinolinone scaffold substituted with chloro, cyclopropylethynyl, and trifluoromethyl groups. This compound matters for its role as a critical building block in modern pharmaceutical research and development, particularly in the synthesis of novel small-molecule therapeutics. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate its distinct structural motifs for enhanced biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Research: Used in the development of new active ingredients for crop protection, leveraging the stability and bioactivity of the trifluoromethyl and quinolinone groups.
• Chemical Biology Probe Development: Employed in creating specialized molecular tools to study enzyme function and protein-ligand interactions within biological systems.
• Material Science Applications: Investigated as a monomer or additive for creating specialty polymers with specific optical or electronic properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthetic routes and scale-up projects.

Basic Information

Product Name	6-Chloro-4-(2-Cyclopropylethynyl)-4-(Trifluoromethyl)-1,3-Dihydroquinolin-2-One
CAS No.	253663-53-5
Molecular Formula	C15H9ClF3NO
Molecular Weight	311.69 g/mol
Synonyms	6-Chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1,3-dihydro-2H-quinolin-2-one; 2H-Quinolin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,3-dihydro-4-(trifluoromethyl)-; 253663-53-5; 6-Chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,3-dihydroquinolin-2-one; 4-(2-Cyclopropylethynyl)-6-chloro-4-(trifluoromethyl)-1,3-dihydroquinolin-2-one
EINECS	Contact for details

Quality Control

Our 6-Chloro-4-(2-Cyclopropylethynyl)-4-(Trifluoromethyl)-1,3-Dihydroquinolin-2-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.