Description

o-(Tetrahydro-2H-Pyran-4-Yl)Hydroxylamine is a versatile hydroxylamine derivative featuring a tetrahydropyranyl (THP) protecting group, which is crucial for its stability and reactivity in advanced synthetic pathways. This compound serves as a key nitrogen-based building block for the construction of complex molecules, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for synthesizing novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its functional group enables the introduction of key pharmacophores.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and performance materials.
• Academic & Contract Research: A valuable reagent for methodological development and exploratory chemistry in university and CRO (Contract Research Organization) laboratories.
• Peptide & Bioconjugate Chemistry: Utilized for the site-specific modification of biomolecules, enabling the creation of antibody-drug conjugates (ADCs) and other bioconjugates.
• Material Science Research: Acts as a functional monomer or cross-linking agent in the development of novel polymers with tailored properties.

Basic Information

Product Name	o-(Tetrahydro-2H-Pyran-4-Yl)Hydroxylamine
CAS No.	252873-77-1
Molecular Formula	C5H11NO2
Molecular Weight	117.15 g/mol
Synonyms	4-(Aminooxy)tetrahydro-2H-pyran; O-(Tetrahydro-2H-pyran-4-yl)hydroxylamine; THP-protected hydroxylamine; 4-(Hydroxyamino)tetrahydro-2H-pyran; Tetrahydro-2H-pyran-4-yloxyamine; 4-Aminoxytetrahydro-2H-pyran; N-(Tetrahydro-2H-pyran-4-yl)hydroxylamine; O-THP-hydroxylamine
EINECS	Contact for details

Quality Control

Our o-(Tetrahydro-2H-Pyran-4-Yl)Hydroxylamine is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.