Description

Ispronicline is a selective nicotinic acetylcholine receptor (nAChR) agonist, specifically targeting the α4β2 subtype. This compound is of significant interest in neuroscience research and pharmaceutical development due to its potential cognitive-enhancing and neuroprotective properties. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for investigating neurological pathways and developing novel therapeutic agents for conditions like cognitive decline and neurodegenerative diseases.

Application

• Neuroscience Research: A key tool compound for studying the function and modulation of α4β2 nicotinic acetylcholine receptors in the central nervous system.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of new therapeutics for cognitive disorders such as Alzheimer's disease and age-related memory impairment.
• Pharmacological Studies: Used in in vitro and in vivo assays to evaluate receptor binding affinity, efficacy, and selectivity profiles.
• Biochemical Screening: Employed in high-throughput screening (HTS) platforms to identify and characterize new chemical entities targeting nAChRs.
• Academic Research: Utilized in university and institutional labs for fundamental research into cholinergic signaling and its role in learning, memory, and neuroprotection.

Basic Information

Product Name	Ispronicline
CAS No.	252870-53-4
Molecular Formula	C11H13N3O
Molecular Weight	203.24 g/mol
Synonyms	TC-1734; AZD-3480; (S)-3-(1-Methyl-2-pyrrolidinyl)pyridine-5-carboxamide; SSR-180711 (Note: SSR-180711 is a distinct but related compound; often referenced in same literature); Ispronicline hydrochloride; TC 1734; AZD 3480; nAChR α4β2 agonist
EINECS	Contact for details

Quality Control

Our Ispronicline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.