Description

4-Methanesulfonyl-2-Methyl-1-Nitrobenzene is a high-purity, synthetically valuable aromatic intermediate featuring both nitro and methanesulfonyl functional groups. This compound is critical for facilitating complex molecular transformations in advanced pharmaceutical and agrochemical research and development. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for constructing novel active ingredients and other specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging its reactive nitro group for further functionalization.
• Material Science Research: Serves as a precursor for developing advanced polymers, liquid crystals, or organic electronic materials due to its electron-withdrawing substituents.
• Dye and Pigment Intermediate: Employed in the synthesis of specialized azo dyes and organic pigments where the sulfonyl and nitro groups influence color and stability properties.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for creating complex biaryl structures prevalent in modern chemistry.
• Chemical Biology Probes: Utilized in the design and synthesis of chemical probes for studying enzyme function and biological pathways.

Basic Information

Product Name	4-Methanesulfonyl-2-Methyl-1-Nitrobenzene
CAS No.	252561-99-2
Molecular Formula	C8H9NO4S
Molecular Weight	215.22 g/mol
Synonyms	2-Methyl-4-(methylsulfonyl)nitrobenzene; 1-Nitro-2-methyl-4-methanesulfonylbenzene; 4-(Methylsulfonyl)-2-methylnitrobenzene; 2-Methyl-1-nitro-4-(methylsulfonyl)benzene; 4-Methylsulfonyl-2-methylnitrobenzene; 2-Methyl-4-methylsulfonylnitrobenzene; Benzene, 1-nitro-2-methyl-4-(methylsulfonyl)-; (2-Methyl-4-(methylsulfonyl)phenyl)nitrate (incorrect but common search variant)
EINECS	Contact for details

Quality Control

Every batch of 4-Methanesulfonyl-2-Methyl-1-Nitrobenzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its properties as a strong oxidizing agent, store separately from combustible materials, reducing agents, and strong acids.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.