Description

Butanoic Acid, 2-Amino-4,4-Difluoro-, Hydrochloride (1:1) is a high-purity, fluorinated amino acid derivative salt, serving as a critical building block in advanced organic synthesis. Its core value lies in providing a difluoromethyl-substituted, chiral backbone essential for constructing complex molecules with tailored properties. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor and enzyme-targeting drug discovery.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the difluoro moiety can enhance metabolic stability and bioavailability.
• Peptide Mimetics & Conformationally Restricted Peptides: Incorporation into peptide chains to study structure-activity relationships (SAR) and improve peptide stability against enzymatic degradation.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Biochemical Research: Utilized as a substrate analog or inhibitor in enzymatic studies to investigate reaction mechanisms and binding sites.
• Material Science: Potential building block for specialty polymers and advanced materials requiring specific fluorine-containing functional groups.

Basic Information

Product Name	Butanoic Acid, 2-Amino-4,4-Difluoro-, Hydrochloride (1:1)
CAS No.	252357-32-7
Molecular Formula	C4H8F2NO2 • HCl
Molecular Weight	185.57 g/mol (Free base: 148.11 g/mol)
Synonyms	2-Amino-4,4-difluorobutanoic acid hydrochloride; 4,4-Difluoro-DL-norvaline hydrochloride; 4,4-Difluoronorvaline HCl; DL-4,4-Difluoronorvaline hydrochloride; (RS)-2-Amino-4,4-difluorobutanoic acid hydrochloride; 2-Azaniumyl-4,4-difluorobutanoate chloride
EINECS	Contact for details

Quality Control

Our Butanoic Acid, 2-Amino-4,4-Difluoro-, Hydrochloride (1:1) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity, NMR for structural confirmation, and KF titration for water content, to ensure it meets the high standards required for research and development. Comprehensive Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.