Description

5-Bromo-3-(Trifluoromethyl)Salicylic Acid, also known as 5-Bromo-3-Carboxy-2-Hydroxybenzotrifluoride, is a high-value, multifunctional aromatic building block that combines a carboxylic acid, a phenolic hydroxyl, and a bromo-trifluoromethyl substitution pattern. This unique structure makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where electronic and steric properties must be precisely tuned. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with enhanced bioactivity and stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in anti-inflammatory, antimicrobial, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis due to its chelating phenolic and carboxylic acid groups.
• Material Science Research: Employed in the synthesis of functional monomers for advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags, photoaffinity labels, and other molecular probes in biochemical research.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses serving the pharmaceutical and agrochemical sectors.

Basic Information

Item	Details
Product Name	5-Bromo-3-(Trifluoromethyl)Salicylic Acid / 5-Bromo-3-Carboxy-2-Hydroxybenzotrifluoride
CAS No.	251300-31-9
Molecular Formula	C8H4BrF3O3
Molecular Weight	285.02 g/mol
Synonyms	5-Bromo-3-(trifluoromethyl)-2-hydroxybenzoic acid; 5-Bromo-2-hydroxy-3-(trifluoromethyl)benzoic acid; 2-Hydroxy-5-bromo-3-(trifluoromethyl)benzoic acid; 5-Bromo-3-trifluoromethylsalicylic acid; 5-Bromo-α,α,α-trifluoro-2-hydroxy-m-toluic acid; BAY 10-8888 (pharmaceutical code); 251300-31-9; 5-Bromo-3-CF3-salicylic acid
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-(Trifluoromethyl)Salicylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements of research and development applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.