Description

(2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}(Methyl)Amino)-3-(4-Fluorophenyl)Propanoic Acid is a sophisticated, optically pure Fmoc-protected amino acid derivative, serving as a critical building block in modern synthetic chemistry. Its primary value lies in enabling the precise, automated synthesis of complex peptides and peptidomimetics, where the Fmoc group provides orthogonal protection and the 4-fluorophenyl side chain introduces specific bioactivity and conformational constraints. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel therapeutic peptides, protease inhibitors, and targeted drug candidates.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the Fmoc-strategy synthesis of fluorinated peptides, enabling the incorporation of the 4-fluorophenylalanine residue.
• Pharmaceutical Intermediates: Used in the research and production of active pharmaceutical ingredients (APIs) for metabolic, oncological, and neurological disorders.
• Peptidomimetic Drug Design: Facilitates the creation of non-natural peptide analogs with enhanced stability, bioavailability, and target specificity.
• Combinatorial Chemistry Libraries: Employed to generate diverse compound libraries for high-throughput screening in drug discovery programs.
• Bioconjugation and Probe Development: Serves as a precursor for fluorescent or affinity probes used in biochemical and diagnostic applications.
• Academic and Industrial R&D: A fundamental reagent for methodological development in organic and medicinal chemistry laboratories worldwide.

Basic Information

Item	Detail
Product Name	(2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}(Methyl)Amino)-3-(4-Fluorophenyl)Propanoic Acid
CAS No.	249648-10-0
Molecular Formula	C25H22FNO4
Molecular Weight	419.45 g/mol
Synonyms	Fmoc-N-Me-4-fluoro-D-phenylalanine; Fmoc-N-Methyl-4-fluoro-D-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-4-fluoro-D-phenylalanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-(4-fluorophenyl)propanoic acid; Nα-Fmoc-Nα-methyl-4-fluoro-D-phenylalanine; Fmoc-D-4-F-Phe(Me)-OH; N-Fmoc-N-methyl-4-fluoro-D-homophenylalanine
EINECS	Contact for details

Quality Control

Every batch of (2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}(Methyl)Amino)-3-(4-Fluorophenyl)Propanoic Acid is manufactured under strict quality management systems. We provide comprehensive analytical documentation, including HPLC chromatograms and chiral purity reports, to ensure the material meets the exacting standards required for peptide synthesis and pharmaceutical R&D. A Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.