Description

Aminooxy-Peg3-Methane CAS NO 248275-10-7 is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive aminooxy group and a terminal methoxy group. This compound is a critical reagent for site-specific bioconjugation, enabling the stable oxime linkage of biomolecules under mild, aqueous conditions. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic assay creation who require precise and stable protein or antibody modifications.

Application

• Antibody-Drug Conjugate (ADC) Linker: For the site-specific conjugation of cytotoxic payloads to monoclonal antibodies via oxime ligation.
• PEGylation Reagent: Used to introduce a hydrophilic PEG spacer to peptides, proteins, or small molecules to improve solubility and pharmacokinetic properties.
• Surface Functionalization: Immobilization of aldehydes or ketones onto aminooxy-functionalized surfaces for biosensor and microarray development.
• Crosslinking Agent: For creating stable oxime bonds between biomolecules in bioconjugate and material science applications.
• Glycan Labeling and Analysis: Conjugation tool for labeling glycoproteins or oligosaccharides containing aldehyde groups for analytical purposes.
• Diagnostic Reagent Synthesis: Key intermediate in the production of enzyme-linked or fluorescently labeled probes for immunoassays.

Basic Information

Product Name	Aminooxy-Peg3-Methane
CAS No.	248275-10-7
Molecular Formula	C11H25NO6
Molecular Weight	267.32 g/mol
Synonyms	3-(2-(2-(2-Methoxyethoxy)ethoxy)ethoxy)propylaminoxy methane; Aminooxy-PEG3-OMe; O-(2-(2-(2-Methoxyethoxy)ethoxy)ethyl)-N-(methoxymethyl)hydroxylamine; Aminooxy-PEG3-methyl ether; Methoxy-PEG3-aminooxy; Aminooxy-triethylene glycol methyl ether; Aminoxy-PEG3-OMe; PEG3-Aminooxy Methyl Ether
EINECS	Contact for details

Quality Control

Our Aminooxy-Peg3-Methane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) with full characterization data are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.