Description

(R)-4-Cyano-3-Hydroxybutanamide is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound matters because its stereochemistry is crucial for the production of active pharmaceutical ingredients (APIs) with specific enantiomeric purity, directly impacting drug efficacy and safety. It is primarily needed by research institutions and manufacturers in the pharmaceutical industry for the development and commercial-scale production of advanced therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of statin-class drugs, such as Atorvastatin and Rosuvastatin, which are used to manage cholesterol.
• API Synthesis: Employed in the research and production of various other Active Pharmaceutical Ingredients (APIs) that require the (R)-enantiomer of the 4-cyano-3-hydroxybutyric acid framework.
• Asymmetric Synthesis: Used in chemical research for developing novel asymmetric catalytic processes and constructing complex molecular architectures.
• Biochemical Research: Serves as a precursor or reference standard in biochemical studies exploring enzyme inhibition and metabolic pathways.
• Fine Chemical Production: Acts as a specialized intermediate in the manufacture of other high-value fine chemicals and advanced materials.

Basic Information

Product Name	(R)-4-Cyano-3-Hydroxybutanamide
CAS No.	244094-04-0
Molecular Formula	C5H8N2O2
Molecular Weight	128.13 g/mol
Synonyms	(R)-4-Cyano-3-hydroxybutyramide; (3R)-4-Cyano-3-hydroxybutanamide; (R)-4-Cyano-3-hydroxybutyric acid amide; (R)-HCA; (R)-3-Hydroxy-4-cyanobutyramide; (R)-3-Hydroxy-4-cyanobutyric acid amide; (R)-4-Cyano-3-hydroxybutyramide; Atorvastatin Intermediate
EINECS	Contact for details

Quality Control

Our (R)-4-Cyano-3-Hydroxybutanamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment to guarantee traceability and support your regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.