Description

5-Fluoro-2-(Trifluoromethyl)Phenol is a high-value fluorinated phenolic compound, serving as a critical building block in advanced chemical synthesis. Its unique structure, featuring both fluorine and trifluoromethyl substituents, imparts significant electronic and steric properties that are highly sought after in the development of novel materials and active ingredients. This intermediate is essential for research and production within the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to create compounds with enhanced stability, bioavailability, and performance.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), improving charge transport and stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to alter thermal properties, chemical resistance, and surface characteristics.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, nucleophilic aromatic substitutions, and as a protecting group precursor in complex multi-step syntheses.
• Research & Development: A valuable compound for academic and industrial R&D in medicinal chemistry, material science, and fluorine chemistry.

Basic Information

Product Name	5-Fluoro-2-(Trifluoromethyl)Phenol
CAS No.	243459-91-8
Molecular Formula	C7H4F4O
Molecular Weight	180.10 g/mol
Synonyms	2-(Trifluoromethyl)-5-fluorophenol; 5-Fluoro-α,α,α-trifluoro-o-cresol; 5-Fluoro-2-trifluoromethylphenol; 2-Hydroxy-5-fluorobenzotrifluoride; 5-Fluorobenzotrifluoride-2-ol; 5-Fluoro-α,α,α-trifluoro-2-cresol; Phenol, 5-fluoro-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-(Trifluoromethyl)Phenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the stringent requirements for use in cGMP pharmaceutical and high-purity agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.